Nephrotoxicity associated with intravenous colistin (colistimethate sodium) treatment at a tertiary care medical center.
نویسندگان
چکیده
The incidence of acute renal failure, defined by the risk, injury, or failure criteria of the RIFLE criteria (risk, injury, failure, loss, and end-stage kidney disease), in 66 patients who received colistimethate sodium was 45%, and 21% of patients stopped therapy because of nephrotoxicity. The RIFLE criteria should be used in the future to allow for comparison of nephrotoxicity among studies.
منابع مشابه
Impact of colistin plasma levels on the clinical outcome of patients with infections caused by extremely drug-resistant Pseudomonas aeruginosa
BACKGROUND Colistin has a narrow therapeutic window with nephrotoxicity being the major dose-limiting adverse effect. Currently, the optimal doses and therapeutic plasma levels are unknown. METHODS Prospective observational cohort study, including patients infected by colistin-susceptible P. aeruginosa treated with intravenous colistimethate sodium (CMS). Clinical data and colistin plasma lev...
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PURPOSE To describe the clinical and microbiological outcomes of patients infected with multidrug-resistant Pseudomonas aeruginosa (MDRP) treated with colistin (colistimethate sodium) and the adverse events observed with this treatment. METHODS Retrospective study of MDRP infections treated with colistin from 1997 to 2006. RESULTS 121 episodes were identified. The median daily intravenous d...
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OBJECTIVE To describe a single center experience involving the administration of colistin to treat nosocomial infections caused by multidrug-resistant Gram-negative bacteria and identify factors associated with acute kidney injury and mortality. METHODS This retrospective longitudinal study evaluates critically ill patients with infections caused by multidrug-resistant Gram-negative bacteria....
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متن کاملThe use of colistin in Cystic Fibrosis
Colistin was first discovered by Koyama et al in 1949, as a fermentation product of the bacteria, Bacillus colistinus (Koyama et al, 1950). In 1959, an intravenous formulation (colistimethate sodium) was released commercially but was then temporarily abandoned in the Seventies and early 1980’s due to reports of a high incidence of nephrotoxicity (Price & Graham, 1970; Koch-Weser et al, 1970) an...
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ورودعنوان ژورنال:
- Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
دوره 48 12 شماره
صفحات -
تاریخ انتشار 2009